Exposure to air pollution and Non-Neoplastic Digestive System Diseases: Findings from The China Health and Retirement Longitudinal Study
ORIGINAL RESEARCH article
Front. Public Health
Sec. Environmental Health and Exposome
Volume 12 – 2024 |
doi: 10.3389/fpubh.2024.1372156
Provisionally accepted
- 1
The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China - 2
Department of Gastroenterology, Huanghe Sanmenxia Hospital, Sanmenxia, China - 3
Department of Cardiovascular Medicine, Huanghe Sanmenxia Hospital, Sanmenxia, China - 4
Department of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
The final, formatted version of the article will be published soon.
Objectives
Increasing concern about air pollution’s impact on public health underscores the need to understand its effects on non-neoplastic digestive system diseases (NNDSD). This study explores the link between air pollution and NNDSD in China.
Methods
We conducted a national cross-sectional study using 2015 data from the China Health and Retirement Longitudinal Study (CHARLS), involving 13,046 Chinese adults aged 45 and above from 28 provinces. Satellite-based spatiotemporal models estimated participants’ exposure to ambient particulate matter (3-year average). An analysis of logistic regression models was conducted to estimate the association between air pollutants (particulate matter with a diameter ≤2.5 μm (PM2.5) or ≤ 10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), and carbon monoxide (CO)) and NNDSD. Interaction analyses were conducted to examine potential modifiers of these associations.
Results
The prevalence of NNDSD among participants was 26.29%. After adjusted for multivariate factors, we observed a 6% (odd ratio (OR)=1.06, 95% confidence interval (CI): 0.94, 1.19), 23% (OR=1.23, 95% CI: 1.09, 1.38), 26% (OR=1.26, 95% CI: 1.12, 1.41), 30% ( OR=1.30,95% CI: 1.16, 1.46), 13% (OR=1.13,95% CI: 1.01, 1.27) and 27% ( OR=1.27,95% CI: 1.13, 1.43) increase in NNDSD risk with an interquartile range increase in PM2.5 (23.36 μg/m3), PM10 (50.33 μg/m3), SO2 (17.27 μg/m3), NO2 (14.75μg/m3), O3 (10.80 μg/m3) and CO (0.42 mg/m3), respectively. Interaction analyses showed that PM2.5, SO2, and O3 had stronger effects on NNDSD risk among older adults, highly educated individuals, smokers, and married people, respectively.
Conclusion
This study demonstrates that long-term exposure to PM2.5, PM10, SO2, NO2, O3 and CO is positively associated with NNDSD risk in Chinese adults aged 45 and above. Implementing intervention strategies to enhance air quality is essential for reducing the burden of NNDSD.
Keywords:
Digestive disease, Air Pollution, Older adult, CHARLS, Chinese
Received:
18 Jan 2024;
Accepted:
30 Oct 2024.
Copyright:
© 2024 Kou, Du, Du, Yang and Qin. This is an
open-access article distributed under the terms of the
Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted,
provided the original author(s) or licensor are credited and that the
original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which
does not comply with these terms.
* Correspondence:
Weiwei Du, Department of Cardiovascular Medicine, Huanghe Sanmenxia Hospital, Sanmenxia, China
Ling Qin, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China
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